Article
Evidence for a locus (IDDM16) in the immunoglobulin heavy chain region on chromosome 14q32.3 producing susceptibility to type 1 diabetes.
Genes and immunity - 1 Sept 2002
Field L L, Larsen Z, Pociot F, Nerup J, Tobias R, Bonnevie-Nielsen V
Abstract excerpt
Type 1 diabetes results from autoimmune destruction of pancreatic islet beta-cells, possibly initiated or exacerbated by viral infections. Recent studies have demonstrated that antibodies towards enterovirus and autoantibodies towards islet cell components develop in the long preclinical phase of type 1 diabetes. We therefore hypothesised that susceptibility to type 1 diabetes could be influenced by genetic...
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