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Article

Double strand break metabolism and cancer susceptibility: lessons from the mre11 complex.

1 May 2004

Abstract excerpt

Hypomorphic mutants affecting the Mre11 complex components Mre11 (Mre11(ATLD1/ATLD1)) and Nbs1 (Nbs1(DeltaB/DeltaB)) have been established in the mouse. These mutations recapitulate those inherited in human chromosome fragility syndromes, the ataxia-telangiectasia like disorder and Nijmegen breakage syndrome. At the cellular level, the human and murine mutants exhibit defects in the intra S and G2/M checkpoints...

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Identifiers

PMID: 15034298
DOI: 10.4161/cc.3.5.835

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