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Article

Craniofacial abnormalities resulting from targeted disruption of the murine Sim2 gene.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Aug 2002

Shamblott M J, Bugg E M, Lawler A M, Gearhart J D

Abstract excerpt

Sim2 is a member of the basic helix-loop-helix PAS transcription factor gene family and is evolutionarily related to the Drosophila single-minded gene, a key regulator of central nervous system midline development. In an effort to determine the biological roles of Sim2 in mammalian development, we disrupted the murine Sim2 gene through gene targeting. Mice homozygous for the disrupted allele (Sim2 -/-) exhibit a...

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PMID: 12203729
DOI: 10.1002/dvdy.10116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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