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Article

Real-time genotyping with oligonucleotide probes containing locked nucleic acids.

Analytical biochemistry - 1 Jan 2004

Ugozzoli Luis A, Latorra David, Puckett Randi, Pucket Randi, Arar Khalil, Hamby Keith

Abstract excerpt

Oligonucleotide probes containing locked nucleic acid (LNA) hybridize to complementary single-stranded target DNA sequences with an increased affinity compared to oligonucleotide DNA probes. As a consequence of the incorporation of LNA residues into the oligonucleotide sequence, the melting temperature of the oligonucleotide increases considerably, thus allowing the successful use of shorter LNA probes as...

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PMID: 14654057
DOI: 10.1016/j.ab.2003.09.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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