Article
Involvement of the zinc-binding capacity of Sendai virus V protein in viral pathogenesis.
Journal of virology - 1 Sept 2000
Huang C, Kiyotani K, Fujii Y, Fukuhara N, Kato A, Nagai Y, Yoshida T, Sakaguchi T
Abstract excerpt
The V protein of Sendai virus (SeV) is nonessential to virus replication in cell culture but indispensable to viral pathogenicity in mice. The highly conserved cysteine-rich zinc finger-like domain in its carboxyl terminus is believed to be responsible for this viral pathogenicity. In the present study, we showed that the cysteine-rich domain of the SeV V protein could actually bind zinc by using...
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