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Article

Suppressive effect of the Gly389 allele of the beta1-adrenergic receptor gene on the occurrence of ventricular tachycardia in dilated cardiomyopathy.

Circulation journal : official journal of the Japanese Circulation Society - 1 Aug 2002

Iwai Chikao, Akita Hozuka, Shiga Nobuyuki, Takai Eiji, Miyamoto Yoshitomo, Shimizu Masakatsu, Kawai Hiroya, Takarada Akira, Kajiya Teishi, Yokoyama Mitsuhiro

Abstract excerpt

Beta-1-adrenergic receptor (beta1-AR) blockers reduce both the incidence of sudden death and the ventricular volume in heart failure. In vitro, the Gly389 variant of beta1-AR mediates less adenylyl cyclase activities than the Arg389 variant, so Arg389Gly polymorphism was investigated with regard to the genesis, progression, or arrhythmogenesis of dilated cardiomyopathy (DCM). Allele and genotype frequencies of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

Share to Receptors, Adrenergic, beta-1

Share to Tachycardia, Ventricular

Source

Identifiers

PMID: 12197595
DOI: 10.1253/circj.66.723

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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