Article
Development of normal retinal organization depends on Sonic hedgehog signaling from ganglion cells.
Nature neuroscience - 1 Sept 2002
Wang Ya Ping, Dakubo Gabriel, Howley Paul, Campsall Katrina D, Mazarolle Chantal J, Shiga Sarah A, Lewis Paula M, McMahon Andrew P, Wallace Valerie A
Abstract excerpt
The adult retina is organized into three cellular layers--an outer photoreceptor, a middle interneuron and an inner retinal ganglion cell (RGC) layer. Although the retinal pigment epithelium (RPE) and Müller cells are important in the establishment and maintenance of this organization, the signals involved are unknown. Here we show that Sonic hedgehog signaling from RGCs is required for the normal laminar...
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