Article
Significant association of longer forms of CCTTT Microsatellite repeat in the inducible nitric oxide synthase promoter with severe malaria in Thailand.
The Journal of infectious diseases - 15 Aug 2002
Ohashi Jun, Naka Izumi, Patarapotikul Jintana, Hananantachai Hathairad, Looareesuwan Sornchai, Tokunaga Katsushi
Abstract excerpt
A CCTTT microsatellite repeat in the inducible nitric oxide synthase (iNOS) promoter was analyzed among 256 adult patients with severe Plasmodium falciparum malaria and 179 adult patients with mild malaria living in northwestern Thailand. Genotypes with longer forms of the CCTTT repeat (alleles of > or =15 repeats) were significantly associated with severe malaria (odds ratio [OR], 2.14; P=.0029, chi(2) test)....
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