Article
Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks.
Developmental cell - 1 Nov 2002
Perea-Gomez Aitana, Vella Francis D J, Shawlot William, Oulad-Abdelghani Mustapha, Chazaud Claire, Meno Chikara, Pfister Veronique, Chen Lan, Robertson Elizabeth, Hamada Hiroshi, Behringer Richard R, Ang Siew-Lan
Abstract excerpt
The anterior visceral endoderm plays a pivotal role in establishing anterior-posterior polarity of the mouse embryo, but the molecular nature of the signals required remains to be determined. Here, we demonstrate that Cerberus-like(-/-);Lefty1(-/-) compound mutants can develop a primitive streak ectopically in the embryo. This defect is not rescued in chimeras containing wild-type embryonic, and...
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