Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hereditary spastic paraplegia: genetic heterogeneity and genotype-phenotype correlation.

Seminars in neurology - 1 Jan 1999

Fink J K, Hedera P

Abstract excerpt

Hereditary spastic paraplegia (HSP) is a group of disorders whose primary symptom is insidiously progressive, lower extremity spasticity and weakness. Neuropathological analysis of "pure" HSP reveals axonal degeneration that is maximal in the terminal portions of the longest descending and ascending tracts (crossed and uncrossed corticospinal tracts to the legs and fasciculus gracilis, respectively). HSP may be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 2
Share to Genetic Linkage
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Hereditary Neurological Disorders

Share to Phenotype

Share to Spastic Paraplegia, Hereditary

Share to Trinucleotide Repeats

Source

Identifiers

PMID: 12194386
DOI: 10.1055/s-2008-1040846

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hereditary spastic paraplegia: genetic heterogeneity and genotype-phenotype correlation.PMID 12194386Read ↗

Hereditary spastic paraplegia: advances in genetic research. Hereditary Spastic Paraplegia Working group.Semantic proximity Read ↗

Hereditary spastic paraplegia: Genetic heterogeneity and common pathways.Semantic proximity Read ↗

Insights into Clinical, Genetic, and Pathological Aspects of Hereditary Spastic Paraplegias: A Comprehensive OverviewSemantic proximity Read ↗

Clinical features and management of hereditary spastic paraplegia.Semantic proximity Read ↗

Hereditary spastic paraplegia: clinical principles and genetic advances.Semantic proximity Read ↗

Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms.Semantic proximity Read ↗

Hereditary spastic paraplegia: clinical features and pathogenetic mechanisms.Semantic proximity Read ↗

Clinical and genetic heterogeneity in hereditary spastic paraplegias: from SPG1 to SPG72 and still counting.Semantic proximity Read ↗

Genetics of hereditary spastic paraplegias.Semantic proximity Read ↗

Hereditary spastic paraplegia.Semantic proximity Read ↗

Hereditary spastic paraplegia: More than an upper motor neuron disease.Semantic proximity Read ↗

Hereditary spastic paraplegia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.