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Article

Disulfide Connectivity of Human Immunoglobulin G2 Structural Isoforms

13 Jun 2008

Abstract excerpt

In this communication we present the detailed disulfide structure of IgG2 molecules. The consensus structural model of human IgGs represents the hinge region positioned as a flexible linker connecting structurally isolated Fc and Fab domains. IgG2 molecules are organized differently from that model and exhibit multiple structural isoforms composed of (heavy chain-light chain-hinge) covalent complexes. We describe...

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PMID: 18549248
DOI: 10.1021/bi800576c

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