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Article

Native interface of the SAM domain polymer of TEL.

BMC structural biology - 22 Aug 2002

Tran Hoang H, Kim Chongwoo A, Faham Salem, Siddall Marie-Claire, Bowie James U

Abstract excerpt

BACKGROUND: TEL is a transcriptional repressor containing a SAM domain that forms a helical polymer. In a number of hematologic malignancies, chromosomal translocations lead to aberrant fusions of TEL-SAM to a variety of other proteins, including many tyrosine kinases. TEL-SAM polymerization results in constitutive activation of the tyrosine kinase domains to which it becomes fused, leading to cell...

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Identifiers

PMID: 12193272
DOI: 10.1186/1472-6807-2-5
PMCID: PMC126206

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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