Article

Optimal TELSAM-Target Protein Linker Character is Target Protein-Dependent

2025-09-02

Abstract excerpt

Fusing a variant of the sterile alpha motif domain of the human translocation ETS leukaemia protein (TELSAM) to a protein of interest has been shown to significantly enhance crystallization propensity. TELSAM is a pH-dependent, polymer-forming protein crystallization chaperone which, when covalently fused to a protein of interest, forms a stable, well-ordered crystal lattice. However, despite its success, a challe...

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Literature Corpus work: db33f59f-7a0f-5b99-9012-7e9a6722ca14
DOI: 10.1101/2025.08.29.672704

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