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Article

Biophysical characterization of the ETV6 PNT domain polymerization interfaces.

The Journal of biological chemistry - 1 Jan 2000

Gerak Chloe A N, Cho Sophia Y, Kolesnikov Maxim, Okon Mark, Murphy Michael E P, Sessions Richard B, Roberge Michel, McIntosh Lawrence P

Abstract excerpt

ETV6 is an E26 transformation specific family transcriptional repressor that self-associates by its PNT domain to facilitate cooperative DNA binding. Chromosomal translocations frequently generate constitutively active oncoproteins with the ETV6 PNT domain fused to the kinase domain of one of many protein tyrosine kinases. Although an attractive target for therapeutic intervention, the propensity of the ETV6 PNT...

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Identifiers

PMID: 33450226
DOI: 10.1016/j.jbc.2021.100284
PMCID: PMC7949025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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