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Article

Reverse genetics in the mosquito Anopheles gambiae: targeted disruption of the Defensin gene.

EMBO reports - 1 Sept 2002

Blandin Stéphanie, Moita Luis F, Köcher Thomas, Wilm Matthias, Kafatos Fotis C, Levashina Elena A

Abstract excerpt

Anopheles gambiae, the major vector of human malaria parasite, is an important insect model to study vector-parasite interactions. Here, we developed a simple in vivo double-stranded RNA (dsRNA) knockout approach to determine the function of the mosquito antimicrobial peptide gene Defensin. We injected dsRNA into adults and observed efficient and reproducible silencing of Defensin. Analysis of the knockdown...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Plasmodium berghei

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Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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Source

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Identifiers

PMID: 12189180
DOI: 10.1093/embo-reports/kvf180
PMCID: PMC1084233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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