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Article

Targeted mutagenesis in the malaria mosquito using TALE nucleases.

PloS one - 1 Jan 2013

Smidler Andrea L, Terenzi Olivier, Soichot Julien, Levashina Elena A, Marois Eric

Abstract excerpt

Anopheles gambiae, the main mosquito vector of human malaria, is a challenging organism to manipulate genetically. As a consequence, reverse genetics studies in this disease vector have been largely limited to RNA interference experiments. Here, we report the targeted disruption of the immunity gene TEP1 using transgenic expression of Transcription-Activator Like Effector Nucleases (TALENs), and the isolation of...

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Identifiers

PMID: 23977401
DOI: 10.1371/journal.pone.0074511
PMCID: PMC3744473

Genes

TEP1

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