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Article

Silencing of genes and alleles by RNAi in Anopheles gambiae.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013

Lamacchia Marina, Clayton John R, Wang-Sattler Rui, Steinmetz Lars M, Levashina Elena A, Blandin Stéphanie A

Abstract excerpt

Anopheles gambiae mosquitoes are the major vectors of human malaria parasites. However, mosquitoes are not passive hosts for parasites, actively limiting their development in vivo. Our current understanding of the mosquito antiparasitic response is mostly based on the phenotypic analysis of gene knockdowns obtained by RNA interference (RNAi), through the injection or transfection of long dsRNAs in adult...

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PMID: 22990777
DOI: 10.1007/978-1-62703-026-7_11

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