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Article

Anopheles gambiae SRPN2 facilitates midgut invasion by the malaria parasite Plasmodium berghei.

EMBO reports - 1 Sept 2005

Michel Kristin, Budd Aidan, Pinto Sofia, Gibson Toby J, Kafatos Fotis C

Abstract excerpt

We report on a phylogenetic and functional analysis of genes encoding three mosquito serpins (SRPN1, SRPN2 and SRPN3), which resemble known inhibitors of prophenoloxidase-activating enzymes in other insects. Following RNA interference induction by double-stranded RNA injection, knockdown of SRPN2 in adult Anopheles gambiae produced a notable phenotype: the appearance of melanotic pseudotumours, which increased in...

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Identifiers

PMID: 16113656
DOI: 10.1038/sj.embor.7400478
PMCID: PMC1369158

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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