Article
Human telomerase reverse transcriptase promoter regulation in normal and malignant human ovarian epithelial cells.
Cancer research - 15 Jul 2001
Braunstein I, Cohen-Barak O, Shachaf C, Ravel Y, Yalon-Hacohen M, Mills G B, Tzukerman M, Skorecki K L
Abstract excerpt
The telomerase RNA-protein complex responsible for maintenance of telomeric DNA at chromosome ends, is usually inactive in most primary somatic human cells, but is specifically activated with in vitro immortalization and during tumorigenesis. Although expression of the RNA component of telomerase appears to be constitutive, the expression pattern of human telomerase reverse transcriptase (hTERT), the catalytic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.