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Ibandronate increases the expression of the pro-apoptotic gene FAS by epigenetic mechanisms in tumor cells

24 Oct 2012

Abstract excerpt

There is growing evidence that aminobisphosphonates like ibandronate show anticancer activity by an unknown mechanism. Biochemically, they prevent posttranslational isoprenylation of small GTPases, thus inhibiting their activity. In tumor cells, activated RAS-GTPase, the founding member of the gene family, down-regulates the expression of the pro-apoptotic gene FAS via epigenetic DNA-methylation by DNMT1. We...

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PMID: 23103563
DOI: 10.1016/j.bcp.2012.10.016

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