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Article

Prenylation inhibition-induced cell death in melanoma: reduced sensitivity in BRAF mutant/PTEN wild-type melanoma cells.

PloS one - 1 Jan 2015

Garay Tamás, Kenessey István, Molnár Eszter, Juhász Éva, Réti Andrea, László Viktória, Rózsás Anita, Dobos Judit, Döme Balázs, Berger Walter, Klepetko Walter, Tóvári József, Tímár József, Hegedűs Balázs

Abstract excerpt

While targeted therapy brought a new era in the treatment of BRAF mutant melanoma, therapeutic options for non-BRAF mutant cases are still limited. In order to explore the antitumor activity of prenylation inhibition we investigated the response to zoledronic acid treatment in thirteen human melanoma cell lines with known BRAF, NRAS and PTEN mutational status. Effect of zoledronic acid on proliferation,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25646931
DOI: 10.1371/journal.pone.0117021
PMCID: PMC4315579

Genes

BRAF
NRAS
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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