Article
A high-resolution allelotype of B-cell chronic lymphocytic leukemia (B-CLL).
Blood - 1 Sept 2002
Novak Urban, Oppliger Leibundgut Elisabeth, Hager Jörg, Mühlematter Dominique, Jotterand Martine, Besse Celine, Leupin Nicolas, Ratschiller Daniel, Papp Jeanette, Kearsey Gina, Aebi Stefan, Graber Hans, Jaggi Rolf, Lüthi Jean-Marc, Meyer-Monard Sandrine, Lathrop Mark, Tobler Andreas, Fey Martin F
Abstract excerpt
The most frequent chromosomal aberrations in B-cell chronic lymphocytic leukemia (B-CLL) are deletions on 13q, 11q, and 17p, and trisomy 12, all of which are of prognostic significance. Conventional cytogenetic analysis and fluorescence in situ hybridization (FISH) are used for their detection, but cytogenetic analysis is hampered by the low mitotic index of B-CLL cells, and FISH depends on accurate information...
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