Article
Improving nucleoside diphosphate kinase for antiviral nucleotide analogs activation.
The Journal of biological chemistry - 18 Oct 2002
Gallois-Montbrun Sarah, Schneider Benoit, Chen Yuxing, Giacomoni-Fernandes Veronique, Mulard Laurence, Morera Solange, Janin Joel, Deville-Bonne Dominique, Veron Michel
Abstract excerpt
Antiviral nucleoside analog therapies rely on their incorporation by viral DNA polymerases/reverse transcriptase leading to chain termination. The analogs (3'-deoxy-3'-azidothymidine (AZT), 2',3'-didehydro-2',3'-dideoxythymidine (d4T), and other dideoxynucleosides) are sequentially converted into triphosphate by cellular kinases of the nucleoside salvage pathway and are often poor substrates of these enzymes....
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