Article
The molecular mechanism of multidrug resistance by the Q151M human immunodeficiency virus type 1 reverse transcriptase and its suppression using alpha-boranophosphate nucleotide analogues.
The Journal of biological chemistry - 1 Nov 2002
Deval Jerome, Selmi Boulbaba, Boretto Joelle, Egloff Marie Pierre, Guerreiro Catherine, Sarfati Simon, Canard Bruno
Abstract excerpt
Nucleoside analogues are currently used to treat human immunodeficiency virus infections. The appearance of up to five substitutions (A62V, V75I, F77L, F116Y, and Q151M) in the viral reverse transcriptase promotes resistance to these drugs, and reduces efficiency of the antiretroviral chemotherapy. Using pre-steady state kinetics, we show that Q151M and A62V/V75I/F77L/F116Y/Q151M substitutions confer to reverse...
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