Article
Genetic polymorphisms of the interleukin-4 receptor alpha gene are associated with an increasing risk and a poor prognosis of sporadic renal cell carcinoma in a Japanese population.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2002
Nakamura Eijiro, Megumi Yuzuru, Kobayashi Takashi, Kamoto Toshiyuki, Ishitoya Satoshi, Terachi Toshiro, Tachibana Mitsuhiro, Matsushiro Hisanori, Habuchi Tomonori, Kakehi Yoshiyuki, Ogawa Osamu
Abstract excerpt
PURPOSE: It has been suggested that the immune system of the host may be capable of modulating the clinical course of renal cell carcinoma (RCC) patients. In fact, the amount of Th2 cytokines such as interleukin (IL)-4 and IL-10 in the serum of patients has been found to be an important predictor of poor prognosis. Recently, it was reported that genetic polymorphisms of the IL-4 receptor alpha (IL-4Ralpha) gene...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.