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Article

Three common polymorphisms in the IL-4 gene and cancer risk: a meta-analysis involving 5,392 cases and 6,930 controls.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Aug 2013

Zhenzhen Li, Xianghua Liu, Qingwei Wang, Zhan Guo, Ning Sun

Abstract excerpt

Interleukin-4 (IL-4) is a typical pleiotropic T helper 2 (Th2) cytokine. This cytokine is a critical mediator of the Th1/Th2 balance and apoptosis potential and involved in the process of inflammation-mediated carcinogenesis in human organs. IL-4 gene polymorphisms influence IL-4 transcription and have been implicated in cancer risks. However, current published data show conflicts among of them. To assess the...

Topics

Carcinoma, Renal Cell
Genetic Predisposition to Disease
Humans
Interleukin-4
Kidney Neoplasms
Mouth Neoplasms
Polymorphism, Single Nucleotide
Risk

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 23572437
DOI: 10.1007/s13277-013-0761-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23572437-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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