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Article

Lamivudine resistance and other mutations in the polymerase and surface antigen genes of hepatitis B virus associated with a fatal hepatic failure case.

Journal of gastroenterology and hepatology - 1 Jan 2008

Bottecchia Marcelle, Ikuta Nilo, Niel Christian, Araujo Natalia M, O Kycia M R, Gomes Selma A

Abstract excerpt

BACKGROUND AND AIM: Resistance to lamivudine therapy of chronic hepatitis B virus (HBV) infection occurs by mutation in the YMDD motif of the reverse transcriptase (rt) domain (rtM204V/I) of the virus polymerase, and is usually accompanied by rtL180M mutation. Here we investigated virological fac...

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Identifiers

PMID: 18171343
DOI: 10.1111/j.1440-1746.2007.05238.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18171343-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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