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Article

Membrane reconstitution of recombinant guinea pig cytochrome P45017alpha and the effects of site-directed mutagenesis on androgen formation.

The Journal of steroid biochemistry and molecular biology - 1 Jul 2002

Owaki Akiko, Takamasa Ayami, Yamazaki Takeshi, Kominami Shiro

Abstract excerpt

Although cytochrome P45017alpha catalyzes the formation of androgen from both pregnenolone and progesterone, the production of androstenedione from progesterone is a major pathway in the guinea pig, rat, mouse, and hamster. In contrast, human, bovine and sheep P45017alpha produce dehydroepiandrosterone from pregnenolone. Cytochrome P45017alphas from all of these animals have high homology in the amino acid...

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PMID: 12163137
DOI: 10.1016/s0960-0760(02)00070-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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