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Article

Lactoferrin reduces in vitro osteoclast differentiation and resorbing activity.

Biochemical and biophysical research communications - 16 Aug 2002

Lorget Florence, Clough Jennifer, Oliveira Manuel, Daury Marc-Cedric, Sabokbar Afsie, Offord Elizabeth

Abstract excerpt

Lactoferrin (LF) is a key modulator of inflammatory response. Since bone and immune systems are genetically and functionally linked, we were interested to know if LF could influence bone remodeling. Bovine LF (bLF) inhibited in vitro bone resorbing activity (IC50, 200 microg/ml) in a rabbit mixed bone cell culture, consisting of authentic osteoclasts in an environment of osteoblast and stromal cells. Using human...

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Source

Identifiers

PMID: 12163011
DOI: 10.1016/s0006-291x(02)00849-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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