Article
IL-6, IL-1β, and TNF-α only in combination influence the osteoporotic phenotype in Crohn's patients via bone formation and bone resorption.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University - 1 Jan 2018
Blaschke Martina, Koepp Regine, Cortis Julia, Komrakova Marina, Schieker Matthias, Hempel Ute, Siggelkow Heide
Abstract excerpt
BACKGROUND: Crohn´s disease (CD) is associated with a higher prevalence of osteoporosis. The pathogenesis of bone affliction remains controversial, especially if inflammatory cytokines or glucocorticoid therapy are the main contributors. In postmenopausal osteoporosis, bone resorption is induced by IL-6, IL-1β and TNF-α. In contrast, in children with CD, IL-6 exclusively decreased bone formation without affecting...
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