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Article

Catalytic mechanism of Sulfiredoxin from Saccharomyces cerevisiae passes through an oxidized disulfide sulfiredoxin intermediate that is reduced by thioredoxin.

The Journal of biological chemistry - 27 Nov 2009

Roussel Xavier, Kriznik Alexandre, Richard Christelle, Rahuel-Clermont Sophie, Branlant Guy

Abstract excerpt

Sulfiredoxin catalyzes the ATP-dependent reduction of overoxidized eukaryotic 2-Cys peroxiredoxin PrxSO(2) into sulfenic PrxSOH. Recent mechanistic studies on sulfiredoxins have validated a catalytic mechanism that includes formation of a phosphoryl intermediate on the sulfinyl moiety of PrxSO(2), followed by an attack of the catalytic cysteine of sulfiredoxin on the phosphoryl intermediate that leads to...

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Identifiers

PMID: 19801666
DOI: 10.1074/jbc.M109.035352
PMCID: PMC2785145

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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