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Article

A mutant epidermal growth factor receptor targeted to lung epithelium inhibits asbestos-induced proliferation and proto-oncogene expression.

Cancer research - 1 Aug 2002

Manning Christopher B, Cummins Andrew B, Jung Michael W, Berlanger Ingrid, Timblin Cynthia R, Palmer Cathy, Taatjes Douglas J, Hemenway David, Vacek Pamela, Mossman Brooke T

Abstract excerpt

Asbestos is a ubiquitous naturally occurring fiber causing multiple cancers and fibroproliferativedisease. The mechanisms of epithelial cell hyperplasia, a hallmark of the initiation of lung cancers by asbestos, have been unclear. We demonstrate here that mice expressing a dominant-negative mutant epidermal growth factor receptor (EGFR) under the control of the human lung surfactant protein-C promoter exhibit...

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Identifiers

PMID: 12154012

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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