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Article

Airway epithelial NF-kappaB activation modulates asbestos-induced inflammation and mucin production in vivo.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2007

Haegens Astrid, Barrett Trisha F, Gell Joanna, Shukla Arti, Macpherson Maximilian, Vacek Pamela, Poynter Matthew E, Butnor Kelly J, Janssen-Heininger Yvonne M, Steele Chad, Mossman Brooke T

Abstract excerpt

To investigate the role of bronchiolar epithelial NF-kappaB activity in the development of inflammation and fibrogenesis in a murine model of asbestos inhalation, we used transgenic (Tg) mice expressing an IkappaBalpha mutant (IkappaBalphasr) resistant to phosphorylation-induced degradation and targeted to bronchial epithelium using the CC10 promoter. Sham and chrysotile asbestos-exposed CC10-IkappaBalphasr Tg(+)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17237430
DOI: 10.4049/jimmunol.178.3.1800

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MIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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