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Article

Altering heparin cofactor II at VAL439 (P6) either impairs inhibition of thrombin or confers elastase resistance.

Thrombosis and haemostasis - 1 Jul 2002

Cunningham Michael A, Bhakta Varsha, Sheffield William P

Abstract excerpt

Heparin cofactor II (HCII) is plasma glycoprotein and thrombin inhibitor of the serpin type previously shown to inhibit thrombin in the absence of its N-terminal 74 amino acids, and to be cleaved by neutrophil elastase (NE) at two sites: I66-F67 and V439-G440, the P6-P5 bond of the reactive center loop. We examined the contribution of Val439 to the reaction of HCII with thrombin and NE. Hexahistidine-tagged HCII...

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PMID: 12152684

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Altering heparin cofactor II at VAL439 (P6) either impairs inhibition of thrombin or confers elastase resistance.PMID 12152684Read ↗

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