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Article

The thrifty epigenotype: an acquired and heritable predisposition for obesity and diabetes?

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Feb 2008

Stöger Reinhard

Abstract excerpt

Obesity and type 2 diabetes arise from a set of complex gene-environment interactions. Explanations for the heritability of these syndromes and the environmental contribution to disease susceptibility are addressed by the "thrifty genotype" and the "thrifty phenotype" hypotheses. Here, the merits of both models are discussed and elements of them are used to synthesize a "thrifty epigenotype" hypothesis. I propose...

Topics

Animals
Diabetes Mellitus
Epigenesis, Genetic
Genetic Predisposition to Disease
Genotype
Humans
Models, Biological
Obesity
Polymorphism, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 18197594
DOI: 10.1002/bies.20700

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