Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Positive selection of a Qa-1-restricted T cell receptor with specificity for insulin.

Immunity - 1 Jul 2002

Sullivan Barbara A, Kraj Piotr, Weber Dominique A, Ignatowicz Leszek, Jensen Peter E

Abstract excerpt

The phenotype and development of T cells from transgenic mice expressing a T cell receptor with specificity for insulin presented by the MHC class Ib molecule Qa-1(b) was investigated. Peripheral T cells from the transgenic mice express CD8 and, after activation, kill Qa-1(b)-positive lymphoid target cells in the presence of soluble insulin. Thymic selection requires expression of Qa-1(b) but not the dominant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Histocompatibility Antigens Class I
Share to Hybridomas
Share to Lymphocyte Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptors, Antigen, T-Cell

Share to Antigen Presentation

Share to Hematopoietic Stem Cells

Share to T-Lymphocytes, Cytotoxic

Share to Thymus Gland

Source

Identifiers

PMID: 12150895
DOI: 10.1016/s1074-7613(02)00343-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Positive selection of a Qa-1-restricted T cell receptor with specificity for insulin.PMID 12150895Read ↗

A narrow T cell receptor repertoire instructs thymic differentiation of MHC class Ib–restricted CD8+ regulatory T cellsSemantic proximity Read ↗

Positive selecting cell type determines the phenotype of MHC class Ib-restricted CD8+ T cells.Semantic proximity Read ↗

Facilitation of β Selection and Modification of Positive Selection in the Thymus of Pd-1–Deficient MiceSemantic proximity Read ↗

The somatically generated portion of T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptor.Semantic proximity Read ↗

Positive selection of MHC class Ib-restricted CD8(+) T cells on hematopoietic cells.Semantic proximity Read ↗

A model for the involvement of MHC class II proteins in the development of type 1 (insulin-dependent) diabetes mellitus in response to bovine serum albumin peptides.Semantic proximity Read ↗

The somatically generated T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptorSemantic proximity Read ↗

High density insulin receptor-positive diabetogenic T lymphocytes in nonobese diabetic mice are memory cells.Semantic proximity Read ↗

Distinct sequence of negative or positive selection implied by thymocyte T-cell receptor densities.Semantic proximity Read ↗

Molecular basis of antigen recognition by insulin specific T cell receptor.Semantic proximity Read ↗

Differential susceptibility to tolerance induction in vitro of splenic B cells from several transgenic mouse lines. Role of B1 cells.Semantic proximity Read ↗

Characterization of the ovalbumin-specific TCR transgenic line OT-I: MHC elements for positive and negative selection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.