Article
Differential susceptibility to tolerance induction in vitro of splenic B cells from several transgenic mouse lines. Role of B1 cells.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1995
Liou L B, Colosia A, Corley R B, Clarke S H, Scott D W
Abstract excerpt
Spleen cells from transgenic mice, whose rearranged Ig receptors reflect the repertoires of B1 (CD5+ and "sister" B cells) or normal B2 cells, were examined for their ability to be rendered unresponsive. By using an anti-Ig tolerance protocol that is independent of receptor specificity, we previo...
Topics
- Animals
- Antibodies, Anti-Idiotypic
- B-Lymphocytes
- Calcium
- Female
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Histocompatibility Antigens Class I
- Immune Tolerance
- In Vitro Techniques
- Lymphocyte Activation
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Phenotype
- Phosphorylation
- Spleen
- Trinitrobenzenes