Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Down syndrome: pathogenesis, radioresistant DNA synthesis and chromosomal instability].

Tsitologiia - 1 Jan 2002

Barenfel'd L S

Abstract excerpt

Down syndrome (DS) is a frequent chromosomal aberration. Triplication of the fragment 21q22 of chromosome 21 is sufficient to cause the DS phenotype including immunodeficiency, premature aging, mental retardation, and an increased risk of leukemia. Chromosomal aberrations caused by X-ray irradiation were observed in DS lymphocytes and DS fibroblasts, but the correlation between chromosomal sensitivity, repair...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Aberrations
Share to Chromosomes, Human, Pair 21
Share to DNA

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Repair

Share to Down Syndrome

Share to Fibroblasts

Share to Lymphocytes

Share to Phenotype

Source

Identifiers

PMID: 12149783

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Down syndrome: pathogenesis, radioresistant DNA synthesis and chromosomal instability].PMID 12149783Read ↗

[Advances of research on the mechanism of Down syndrome birth at advanced maternal age].Semantic proximity Read ↗

Trisomy 21: conference report and 1990 update.Semantic proximity Read ↗

[Free radicals in the origin and clinical manifestation of Down's syndrome].Semantic proximity Read ↗

Down syndrome, drug metabolism and chromosome 21Semantic proximity Read ↗

[Mutations in the methylene-tetrahydrofolate reductase gene and Down syndrome].Semantic proximity Read ↗

Carcinogenesis in Down syndrome: what can be learned from trisomy 21?Semantic proximity Read ↗

[New perspectives on molecular and genic therapies in Down syndrome].Semantic proximity Read ↗

[The peculiarities of polymorphism of XPD and XRCC1 repair genes in cells of Down and Ehlers-Danlo syndrome patients characterized by increased radiosensitivity].Semantic proximity Read ↗

Trisomy 21 and accelerated aging: DNA-repair parameters in peripheral lymphocytes of Down's syndrome patientsSemantic proximity Read ↗

Malignancies in Down syndrome.Semantic proximity Read ↗

Down syndrome as a model of DNA polymerase beta haploinsufficiency and accelerated aging.Semantic proximity Read ↗

Mitochondrial dysfunction and Down's syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.