Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial dysfunction and Down's syndrome.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Aug 2002

Arbuzova Svetlana, Hutchin Tim, Cuckle Howard

Abstract excerpt

Neither the pathogenesis nor the aetiology of Down's syndrome (DS) are clearly understood. Numerous studies have examined whether clinical features of DS are a consequence of specific chromosome 21 segments being triplicated. There is no evidence, however, that individual loci are responsible, or that the oxidative damage in DS could be solely explained by a gene dosage effect. Using astrocytes and neuronal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Oxidative Stress
Share to Amyloid beta-Peptides
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down Syndrome

Share to Mitochondria

Share to Mutation

Share to Neurons

Share to Superoxide Dismutase

Source

Identifiers

PMID: 12210526
DOI: 10.1002/bies.10138

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial dysfunction and Down's syndrome.PMID 12210526Read ↗

Mitochondrial dysfunction in down syndrome: molecular mechanisms and therapeutic targetsSemantic proximity Read ↗

Oxidative Stress and Mitochondrial Dysfunction in Down’s Syndrome: Relevance to Aging and DementiaSemantic proximity Read ↗

Oxidative stress, thyroid dysfunction & Down syndromeSemantic proximity Read ↗

Down syndrome phenotypes: the consequences of chromosomal imbalance.Semantic proximity Read ↗

Down Syndrome Is a Metabolic Disease: Altered Insulin Signaling Mediates Peripheral and Brain DysfunctionsSemantic proximity Read ↗

Beta-amyloid, oxidative stress and down syndrome.Semantic proximity Read ↗

[Mutations in the methylene-tetrahydrofolate reductase gene and Down syndrome].Semantic proximity Read ↗

Oxidative Stress and Down Syndrome: A Route toward Alzheimer-Like DementiaSemantic proximity Read ↗

Synthetic combinations of missense polymorphic genetic changes underlying Down syndrome susceptibility.Semantic proximity Read ↗

Beta-amyloid precursor protein, ETS-2 and collagen alpha 1 (VI) chain precursor, encoded on chromosome 21, are not overexpressed in fetal Down syndrome: further evidence against gene dosage effect.Semantic proximity Read ↗

Down syndrome is an oxidative phosphorylation disorderSemantic proximity Read ↗

Mitochondrial dysfunction and tau hyperphosphorylation in Ts1Cje, a mouse model for Down syndromeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.