Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Advances of research on the mechanism of Down syndrome birth at advanced maternal age].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 10 Dec 2016

Chu Nan, Zhang Yueping, Zhang Bin

Abstract excerpt

Down syndrome is caused by partial or complete triplication of genes located on chromosome 21. Its incidence increases dramatically with the age of women. Hypotheses proposed for this have included abnormal homologous recombination, defective spindle assembly, biological aging, reduction of cohesion complexes, endocrine disorders, oocyte selection model, and single nucleotide polymorphisms of genes that maintain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Chromosomes, Human, Pair 21

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Down Syndrome

Share to Maternal Age

Share to Oocytes

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 27984623
DOI: 10.3760/cma.j.issn.1003-9406.2016.06.026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Advances of research on the mechanism of Down syndrome birth at advanced maternal age].PMID 27984623Read ↗

[Free radicals in the origin and clinical manifestation of Down's syndrome].Semantic proximity Read ↗

Molecular mechanisms of congenital heart disease in down syndromeSemantic proximity Read ↗

Nondisjunction in Trisomy 21: Origin and MechanismsSemantic proximity Read ↗

The 50th anniversary of the discovery of trisomy 21: the past, present, and future of research and treatment of Down syndrome.Semantic proximity Read ↗

[Meiotic and parental origin of extra chromosome 21 in children with regular trisomy 21].Semantic proximity Read ↗

[Clinical, epidemiological and cytogenetic studies on 221 patients with Down syndrome].Semantic proximity Read ↗

Down syndrome: Comments and reflections on the 50th anniversary of Lejeune's discoverySemantic proximity Read ↗

Cytogenetic and epidemiological findings in Down syndrome: England and Wales 1989–2009Semantic proximity Read ↗

Trisomy 21: conference report and 1990 update.Semantic proximity Read ↗

Genetic mechanisms involved in the phenotype of Down syndrome.Semantic proximity Read ↗

Down syndrome genetics: unravelling a multifactorial disorder.Semantic proximity Read ↗

Chromosome 21 and down syndrome: from genomics to pathophysiology.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.