Article
Myelin oligodendrocyte gene polymorphisms and childhood multiple sclerosis.
Pediatric research - 1 Aug 2002
Ohlenbusch Andreas, Pohl Daniela, Hanefeld Folker
Abstract excerpt
Myelin oligodendrocyte glycoprotein (MOG) is a quantitatively minor glycoprotein of the CNS localized preferentially on the outermost myelin lamellae and the oligodendrocyte plasma membrane. In several animal models, MOG displays highly immunogenic properties by inducing a severe multiple sclerosis-like disease, characterized by inflammatory demyelinating lesions. Immunologic findings implicate MOG as a target...
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