Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A missense mutation in kynurenine aminotransferase-1 in spontaneously hypertensive rats.

The Journal of biological chemistry - 27 Sept 2002

Kwok John B J, Kapoor Ranjna, Gotoda Takanari, Iwamoto Yasuhiko, Iizuka Yoko, Yamada Nobuhiro, Isaacs Kim E, Kushwaha Virag V, Church W Bret, Schofield Peter R, Kapoor Vimal

Abstract excerpt

Spontaneously hypertensive rats (SHR) are the most extensively used animal model for genetic hypertension, increased stroke damage, and insulin resistance syndromes; however, the identification of target genes has proved difficult. SHR show elevated sympathetic nerve activity, and stimulation of the central blood pressure control centers with glutamate or nicotine results in exaggerated blood pressure responses,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Western
Share to DNA, Complementary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoresis, Polyacrylamide Gel

Share to Mutation, Missense

Share to Protein Structure, Secondary

Share to Rats, Inbred SHR

Share to Rats, Wistar

Share to Transaminases

Source

Identifiers

PMID: 12145272
DOI: 10.1074/jbc.C200303200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

A missense mutation in kynurenine aminotransferase-1 in spontaneously hypertensive rats.PMID 12145272Read ↗

Altered angiotensinogen amino acid sequence and plasma angiotensin II levels in genetically hypertensive rats. A study on cause and effect.Semantic proximity Read ↗

Identification of a novel polymorphism in the 3'UTR of the L-arginine transporter gene SLC7A1: contribution to hypertension and endothelial dysfunction.Semantic proximity Read ↗

Mutant animal models of stroke and gene expression: the stroke-prone spontaneously hypertensive rat.Semantic proximity Read ↗

Alteration of alpha 1 Na+,K(+)-ATPase 86Rb+ influx by a single amino acid substitution.Semantic proximity Read ↗

The Atp1a1 gene from inbred Dahl salt sensitive rats does not contain the A1079T missense transversion.Semantic proximity Read ↗

Mutation of the trkB gene encoding the high-affinity receptor for brain-derived neurotrophic factor in stroke-prone spontaneously hypertensive rats.Semantic proximity Read ↗

Sulfhydryl modification of cysteine mutants of a neuronal glutamate transporter reveals an inverse relationship between sodium dependent conformational changes and the glutamate-gated anion conductance.Semantic proximity Read ↗

Adenosine A1 receptor gene structure and regulation in normotensive and spontaneously hypertensive rats.Semantic proximity Read ↗

Nitric oxide synthase (NOS2) mutation in Dahl/Rapp rats decreases enzyme stability.Semantic proximity Read ↗

Spontaneously hypertensive rats are highly vulnerable to AMPA-induced brain lesions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.