Article
Mutation of the trkB gene encoding the high-affinity receptor for brain-derived neurotrophic factor in stroke-prone spontaneously hypertensive rats.
Biochemical and biophysical research communications - 24 Dec 1996
Kageyama H, Nemoto K, Nemoto F, Sekimoto M, Nara Y, Nabika T, Iwayama Y, Fukamachi K, Tomita I, Senba E, Forehand C J, Hendley E D, Ueyama T
Abstract excerpt
Brain-derived neurotrophic factor and its receptor, trkB, are thought to play a crucial role for protection against neuronal death induced by brain ischemia, such as in stroke. In the present study we found a missense mutation in the trkB gene from all of the five substrains of stroke-prone spontaneously hypertensive rats (SHRSP) that were examined. This mutation was not found in six out of seven hypertensive but...
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