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Article

Apolipoprotein E-ε4 deficiency and cognitive function in hepatitis C virus-infected patients.

Journal of viral hepatitis - 1 Jan 2016

Wozniak M A, Lugo Iparraguirre L M, Dirks M, Deb-Chatterji Milani, Pflugrad H, Goldbecker A, Tryc A B, Worthmann H, Gess M, Crossey M M E, Forton D M, Taylor-Robinson S D, Itzhaki R F, Weissenborn K

Abstract excerpt

Hepatitis C virus (HCV) causes not only liver damage in certain patients but can also lead to neuropsychiatric symptoms. Previous studies have shown that the type 4 allele of the gene for apolipoprotein E (APOE) is strongly protective against HCV-induced damage in liver. In this study, we have investigated the possibility that APOE genotype is involved in the action of HCV in brain. One hundred HCV-infected...

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Source

Identifiers

PMID: 26306786
DOI: 10.1111/jvh.12443

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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