Article
Human leukocyte antigen class II alleles may contribute to the severity of hepatitis C virus-related liver disease.
The Journal of infectious diseases - 1 Jul 2002
Hüe Sophie, Cacoub Patrice, Renou Christophe, Halfon Philippe, Thibault Vincent, Charlotte Frédéric, Picon Magali, Rifflet Hervé, Piette Jean Charles, Pol Stanislas, Caillat-Zucman Sophie
Abstract excerpt
Whether the host's immune response genes influence the severity of hepatitis C virus (HCV) liver disease is controversial. Human leukocyte antigen (HLA) class II alleles were analyzed in 233 HCV RNA-positive patients with chronic active hepatitis (197 patients with Knodell index of fibrosis F0-F3 and 36 patients with index of F4). The 2 groups did not differ by sex, duration of infection, mode of contamination,...
Topics
- Adolescent
- Adult
- Age Factors
- Aged
- Alleles
- Female
- Genetic Markers
- HLA-DR Antigens
- HLA-DR Serological Subtypes
- HLA-DR3 Antigen
- HLA-DRB1 Chains
- Hepatitis C
- Histocompatibility Antigens Class II