Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hepatocytes undergo phenotypic transformation to biliary epithelium in organoid cultures.

Hepatology (Baltimore, Md.) - 1 Aug 2002

Michalopoulos George K, Bowen William C, Mulè Karen, Lopez-Talavera Juan Carlos, Mars Wendy

Abstract excerpt

Organoid cultures of hepatocytes in the presence of hepatocyte growth factor (HGF) and epidermal growth factor (EGF) display characteristic histologic organization. Biliary epithelium covers the surface of the tissue exposed to the culture medium. Hepatocytes, stellate cells and endothelial cells compose the underlying structures. In order to investigate the origin of the biliary epithelial cells in the organoid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers
Share to Dipeptidyl Peptidase 4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial Cells

Share to Hepatocytes

Share to Organ Culture Techniques

Share to Rats, Inbred F344

Share to Staining and Labeling

Source

Open in PubMed Open full text

Identifiers

PMID: 12143035
DOI: 10.1053/jhep.2002.34858
PMCID: PMC1769334

Genes

EGF
HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hepatocytes undergo phenotypic transformation to biliary epithelium in organoid cultures.PMID 12143035Read ↗

Cholangiocyte marker-positive and -negative fetal liver cells differ significantly in their ability to regenerate the livers of adult rats exposed to retrorsine.Semantic proximity Read ↗

Biliary fibrosis drives liver repopulation and phenotype transition of transplanted hepatocytes.Semantic proximity Read ↗

Differentiation of pancreatic epithelial progenitor cells into hepatocytes following transplantation into rat liverSemantic proximity Read ↗

Hepatocytes differentiate into intestinal epithelial cells through a hybrid epithelial/mesenchymal cell state in cultureSemantic proximity Read ↗

Timing and sequence of differentiation of embryonic rat hepatocytes along the biliary epithelial lineage.Semantic proximity Read ↗

Evidence for a common progenitor of epithelial and mesenchymal components of the liverSemantic proximity Read ↗

Mature hepatocytes exhibit unexpected plasticity by direct dedifferentiation into liver progenitor cells in culture.Semantic proximity Read ↗

Stem cell properties and repopulation of the rat liver by fetal liver epithelial progenitor cells.Semantic proximity Read ↗

Liver repopulation and correction of metabolic liver disease by transplanted adult mouse pancreatic cells.Semantic proximity Read ↗

Liver Repopulation after Hepatocellular Transplantation: Integration and Interaction of Transplanted Hepatocytes in the HostSemantic proximity Read ↗

Isolation, characterization, and differentiation to hepatocyte-like cells of nonparenchymal epithelial cells from adult human liver.Semantic proximity Read ↗

An improved polarized rat hepatoma hybrid cell line: generation and comparison with its hepatoma relatives and hepatocytes in vivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.