Article
Liver repopulation and correction of metabolic liver disease by transplanted adult mouse pancreatic cells.
The American journal of pathology - 1 Feb 2001
Wang X, Al-Dhalimy M, Lagasse E, Finegold M, Grompe M
Abstract excerpt
The emergence of cells with hepatocellular properties in the adult pancreas has been described in several experimental models. To determine whether adult pancreas contains cells that can give rise to therapeutically useful and biochemically normal hepatocytes, we transplanted suspensions of wild-type mouse pancreatic cells into syngeneic recipients deficient in fumarylacetoacetate hydrolase and manifesting...
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