Article
Polymorphisms of the nuclear receptor pregnane X receptor and organic anion transporter polypeptides 1A2, 1B1, 1B3, and 2B1 are not associated with breast cancer risk.
Breast cancer research and treatment - 1 Jan 2011
Justenhoven Christina, Schaeffeler Elke, Winter Stefan, Baisch Christian, Hamann Ute, Harth Volker, Rabstein Sylvia, Spickenheuer Anne, Pesch Beate, Brüning Thomas, Ko Yon-Dschun, Schwab Matthias, Brauch Hiltrud
Abstract excerpt
Organic anion transporter polypeptides (OATPs, SLCOs) are involved in the uptake of conjugates steroid hormones such as estrone-3-sulfate. It has been suggested that the expression of OATPs in breast tissues could impact breast carcinogenesis and tumor pathology. The nuclear receptor pregnane X receptor (PXR) is involved in the regulation of SLCO1A2 expression. We investigated 31 variants located in PXR, SLCO1A2,...
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