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<i>Helicobacter pylori</i> SabA Adhesin in Persistent Infection and Chronic Inflammation

26 Jul 2002

Abstract excerpt

Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H. pylori and show that H. pylori infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. The corresponding sialic acid-binding adhesin (SabA) was isolated with...

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PMID: 12142529
DOI: 10.1126/science.1069076

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