Article
Novel mutation and RNA splice variant of fibroblast growth factor receptor 3 in multiple myeloma patients at diagnosis.
Haematologica - 1 Oct 2002
Soverini Simona, Terragna Carolina, Testoni Nicoletta, Ruggeri Deborah, Tosi Patrizia, Zamagni Elena, Cellini Claudia, Cavo Michele, Baccarani Michele, Tura Sante, Martinelli Giovanni
Abstract excerpt
BACKGROUND AND OBJECTIVES: The karyotypically silent t(4;14)(p16.3;q32) translocation can be found in approximately 15-20% of multiple myeloma (MM) patients and results in the ectopic expression of fibroblast growth factor receptor 3 (FGFR3) from der4. Point mutations in specific FGFR3 domains can be found in the translocated allele, and have been recently proven to be oncogenic. These mutations produce a...
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